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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Marta Kostyuk | Win | 6-2, 6-1 |
| Second Round | Ajla Tomljanovic | Win | Retired |
| Third Round | Sorana Cirstea | Loss | 3-6, 7-6 (8-6), 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jelena Ostapenko | Win | 6-7 (6-8), 6-2, 6-4 |
| Third Round | Jasmine Paolini | Loss | 6-4, 2-5 Retired |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jennifer Brady | Win | 6-7 (3-7), 7-6 (7-5), 6-3 |
| Third Round | Sloane Stephens | Win | 6-3, 6-3 |
| Quarterfinals | Daria Kasatkina | Win | 5-7, 7-5, 7-6 (10-8) |
| Semifinals | Liudmila Samsonova | Loss | 6-1, 1-6, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Win | |
| Second Round | Alize Cornet | Win | |
| Third Round | Katie Boulter | Win | |
| Fourth Round | Beatriz Haddad Maia | Win | |
| Quarterfinals | Ons Jabeur | Loss |
| Bett1 Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Polina Kudermetova | Win | |
| Second Round | Donna Vekic | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Brenda Fruhvirtova | Win | |
| Second Round | Linda Noskova | Win | |
| Third Round | Sara Sorribes Tormo | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jasmine Paolini | Win | |
| Third Round | Anna Kalinskaya | Win | |
| Fourth Round | Marketa Vondrousova | Win | |
| Quarterfinals | Iga Swiatek | Win | |
| Semifinals | Jelena Ostapenko | Win | |
| Final | Anhelina Kalinina | Win |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 25 - May 6 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Kalinskaya | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Jule Niemeier | Win | |
| Second Round | Beatriz Haddad Maia | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Kalinskaya | Win | |
| Third Round | Paula Badosa | Win | |
| Fourth Round | Elise Mertens | Win | |
| Quarterfinals | Martina Trevisan | Win | |
| Semifinals | Jessica Pegula | Win | |
| Final | Petra Kvitova | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sofia Kenin | Win | |
| Third Round | Paula Badosa | Win | |
| Fourth Round | Varvara Gracheva | Win | |
| Quarterfinals | Karolina Muchova | Win | |
| Semifinals | Iga Swiatek | Win | |
| Final | Aryna Sabalenka | Win |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bianca Andreescu | Win | |
| Second Round | Marie Bouzkova | Win | |
| Third Round | Coco Gauff | Loss |
| Mubadala Abu Dhabi Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Karolina Pliskova | Win | |
| Quarterfinals | Beatriz Haddad Maia | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Elisabetta Cocciaretto | Win | |
| Second Round | Kaja Juvan | Win | |
| Third Round | Danielle Collins | Win | |
| Fourth Round | Iga Swiatek | Win | |
| Quarterfinals | Jelena Ostapenko | Win | |
| Semifinals | Victoria Azarenka | Win | |
| Final | Aryna Sabalenka | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Kvitova | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Dec. 31 - Jan. 8 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Danielle Collins | Win | |
| Second Round | Marta Kostyuk | Loss |
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