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| Roland Garros | ||
| Surface: Red Clay | Date: Sep. 27 - Oct. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Marin Cilic |
| US Open | ||
| Surface: Hard | Date: Aug. 31 - Sep. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jaume Munar | Win | 7-6 (8-6), 6-3, 0-0 Retired |
| Second Round | Sumit Nagal | Win | 6-3, 6-3, 6-2 |
| Third Round | Marin Cilic | Win | 6-2, 6-2, 3-6, 6-3 |
| Fourth Round | Felix Auger-Aliassime | Win | 7-6 (7-4), 6-1, 6-1 |
| Quarterfinals | Alex De Minaur | Win | 6-1, 6-2, 6-4 |
| Semifinals | Daniil Medvedev | Win | 6-2, 7-6 (9-7), 7-6 (7-5) |
| Final | Alexander Zverev | Win | 2-6, 4-6, 6-4, 6-3, 7-6 (8-6) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 22 - Aug. 29 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Filip Krajinovic | Loss | 2-6, 1-6 |
| Rio Open presented by Claro HDTV | ||
| Surface: Clay | Date: Feb. 17 - Feb. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Felipe Meligeni Rodrigues Alves | Win | 6-2, 4-6, 6-1 |
| Second Round | Jaume Munar | Win | 6-7 (5-7), 6-3, 6-4 |
| Quarterfinals | Gianluca Mager | Loss | 6-7 (4-7), 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 20 - Feb. 2 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Adrian Mannarino | Win | 6-3, 7-5, 6-2 |
| Second Round | Alex Bolt | Win | 6-2, 5-7, 6-7 (5-7), 6-1, 6-2 |
| Third Round | Taylor Fritz | Win | 6-2, 6-4, 6-7 (5-7), 6-4 |
| Fourth Round | Gael Monfils | Win | 6-2, 6-4, 6-4 |
| Quarterfinals | Rafael Nadal | Win | 7-6 (7-3), 7-6 (7-4), 4-6, 7-6(8-6) |
| Semifinals | Alexander Zverev | Win | 3-6, 6-4, 7-6 (7-3), 7-6(7-4) |
| Final | Novak Djokovic | Loss | 4-6, 6-4, 6-2, 3-6, 4-6 |
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