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| Rolex Paris Masters | ||
| Surface: Hard | Date: Nov. 1 - Nov. 7 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire | Win | 6-3, 6-4 |
| Second Round | Hugo Gaston | Loss | 7-6 (7-3), 4-6, 5-7 |
| Erste Bank Open 500 | ||
| Surface: Hard | Date: Oct. 25 - Oct. 31 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Nikoloz Basilashvili | Loss | 5-7, 6-4, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emilio Gomez | Win | 6-1, 6-4 |
| Third Round | Karen Khachanov | Loss | 0-6, 4-6 |
| Moselle Open | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikael Ymer | Win | 7-5, 6-2 |
| Quarterfinals | Holger Vitus Nodskov Rune | Win | 6-4, 3-6, 6-4 |
| Semifinals | Gael Monfils | Win | 7-5, 7-6 (10-8) |
| Final | Hubert Hurkacz | Loss | 6-7 (2-7), 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Maxime Cressy | Loss | 7-5, 6-4, 1-6, 4-6, 6-7 (7-9) |
| Winston-Salem Open | ||
| Surface: Hard | Date: Aug. 22 - Aug. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Soon Woo Kwon | Win | 6-3, 3-6, 6-4 |
| Third Round | Dominik Koepfer | Win | 6-2, 6-3 |
| Quarterfinals | Ilya Ivashka | Loss | 6-7 (2-7), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominik Koepfer | Win | 6-4, 6-2 |
| Third Round | Hubert Hurkacz | Win | 7-6 (8-6), 7-6 (7-3) |
| Quarterfinals | Daniil Medvedev | Loss | 1-6, 1-6 |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 12 - Jul. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Carlos Taberner | Win | 7-5, 6-3 |
| Quarterfinals | Dusan Lajovic | Win | 7-6 (7-4), 6-3 |
| Semifinals | Federico Delbonis | Win | 7-6 (7-2), 6-3 |
| Final | Filip Krajinovic | Win | 6-2, 6-4 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Sam Querrey | Loss | 6-7 (6-8), 4-6, 5-7 |
| Mallorca Championships | ||
| Surface: Grass | Date: Jun. 20 - Jun. 26 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Vesely | Win | 6-4, 6-4 |
| Quarterfinals | Jordan Thompson | Win | 6-4, 6-4 |
| Semifinals | Daniil Medvedev | Loss | 6-3, 3-6, 2-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Norbert Gombos | Win | 6-3, 6-4, 6-3 |
| Second Round | Enzo Couacaud | Win | 2-6, 6-3, 6-4, 6-4 |
| Third Round | Steve Johnson | Win | 6-4, 6-4, 6-2 |
| Fourth Round | Stefanos Tsitsipas | Loss | 3-6, 2-6, 5-7 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Laslo Djere | Win | 4-6, 6-3, 6-1 |
| Second Round | Kei Nishikori | Loss | Retired |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Federico Delbonis | Loss | 6-3, 4-6, 3-6 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jordan Thompson | Win | 6-4, 6-0 |
| Third Round | Bernabe Zapata Miralles | Win | 6-3, 6-4 |
| Quarterfinals | Diego Schwartzman | Win | 6-4, 3-6, 7-5 |
| Semifinals | Rafael Nadal | Loss | 3-6, 2-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 11 - Apr. 18 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Stefano Travaglia | Win | 7-5, 7-6 (7-4) |
| Second Round | Karen Khachanov | Win | 6-2, 6-3 |
| Third Round | Casper Ruud | Loss | 6-7 (4-7), 7-5, 5-7 |
| AnyTech365 Andalucia Open | ||
| Surface: Red Clay | Date: Apr. 5 - Apr. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mario Vilella Martinez | Win | 7-6 (7-2), 6-3 |
| Quarterfinals | Soon Woo Kwon | Win | 6-4, 6-0 |
| Semifinals | Albert Ramos-Vinolas | Win | 6-1, 3-6, 7-6 (7-5) |
| Final | Jaume Munar | Win | 6-1, 2-6, 6-4 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 14 - Mar. 20 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Loss | 7-6 (7-5), 3-6, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Kei Nishikori | Win | 7-5, 7-6 (7-4), 6-2 |
| Second Round | Jiri Vesely | Win | 6-3, 7-6 (7-3), 2-6, 6-4 |
| Third Round | Grigor Dimitrov | Loss | 0-6, 0-1 Retired |
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