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| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Hyeon Chung | Loss | 6-2, 1-6, 2-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Daniil Medvedev | Loss | 3-6, 6-3, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Matteo Berrettini | Loss | 7-6 (7-5), 7-6 (7-3), 4-6, 5-7, 2-6 |
| Fever-Tree Championships | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Daniil Medvedev | Loss | 5-7, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Jurgen Zopp | Loss | 7-6 (7-4), 2-6, 6-4, 6-7 (5-7), 3-6 |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 20 - May 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Fritz | Loss | 6-7 (6-8), 2-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | David Ferrer | Win | 6-3, 6-4 |
| Second Round | Philipp Kohlschreiber | Loss | 4-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Pablo Cuevas | Loss | 7-6 (7-5), 4-6, 0-6 |
| Fayez Sarofim & Co. US Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 9 - Apr. 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Horacio Zeballos | Win | 6-4, 6-4 |
| Quarterfinals | Taylor Fritz | Loss | 3-6, 6-3, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yuki Bhambri | Win | 6-3, 7-6 (7-3) |
| Third Round | Borna Coric | Loss | 7-5, 6-7 (4-7), 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thomas Fabbiano | Win | 6-2, 7-5 |
| Third Round | Feliciano Lopez | Loss | 6-7 (6-8), 6-4, 4-6 |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 26 - Mar. 3 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Ernesto Escobedo | Loss | 5-7, 6-7 (3-7) |
| Delray Beach Open | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | John-Patrick Smith | Win | 6-4, 6-4 |
| Second Round | Reilly Opelka | Loss | 6-4, 5-7, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Yuichi Sugita | Loss | 1-6, 6-7 (4-7), 7-5, 3-6 |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 1 - Jan. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Peter Gojowczyk | Loss | 3-6, 3-6 |
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